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Generics is a medicines that has the same qualitative and quantitative composition of active ingredients and the same pharmaceutical form as the original medicine.
The main difference lies in the name: the generic gets the name of the medicinal substance included in its composition. Generics are released to the market after the original drug patent expires.
The main advantage of generics lies in the savings in the final sale price to the consumer, which can be up to 90% less than the price of the original drug, since the investment made by the pharmaceutical company initially in the discovery does not affect the generic drug.
The quality of generics is the same as that of the originator drug, as generics are subject to the same procedures and controls as any other drug.
Typically, generic versus brand-name controversies focus on the economic side. But we want to touch on another aspect: are generic and branded drugs really the same thing? Do they heal as effectively as the parental medication?
The first and most basic question is whether the generic formulation is the same as the brand-name drug. The almost unanimous answer is yes ... one with some nuances. These nuances are related to the second question: if a drug is an active ingredient plus any excipient, and the excipient (which marks problems such as the rate of absorption or stability of the active ingredient) is different, how can the drugs be the same? The answer here fluctuates between two metaphors. First, "the lenses of your glasses and mine may have a different composition and they are made in different places, but they solve one problem", that is, a different composition can give, thanks to the identical active ingredient, the same effect. ... and Second, "a car with a Mercedes engine is not necessarily a Mercedes", that is, an equal active ingredient mixed with another modification of the excipient. medicine. and also successfully such an opinion "The active principle is the same, but the excipient is different, and the excipient can add or subtract, introducing nuances, which may be important for some patients."
Here such concepts as bioequivalence, bioavailability, pharmacokinetics, pharmacodynamics, and plasma concentration appear. The fact that the generic contains the same active ingredient and approved excipient, and that this blend has been tested by pharmaceutical agencies, means that it achieves behavioral parameters similar to those of the brand name drug it replaces, in terms of stability and effectiveness, or presence in the blood and maintaining concentration curves in the body for an appropriate period of time.